Src Inhibition Ameliorates Polycystic Kidney Disease

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Src inhibition ameliorates polycystic kidney disease.

Despite identification of the genes responsible for autosomal dominant polycystic kidney disease (PKD) and autosomal recessive PKD (ARPKD), the precise functions of their cystoprotein products remain unknown. Recent data suggested that multimeric cystoprotein complexes initiate aberrant signaling cascades in PKD, and common components of these signaling pathways may be therapeutic targets. This...

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Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.

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P olycystic kidney disease (PKD) has a number of characteristics that make it uniquely challenging for the development of therapies to slow disease progression. Renal cystic diseases result from the neoplastic growth of numerous fluid-filled cysts, often accompanied by increased apoptosis, tissue remodeling, inflammation, and fibrosis (1–3). The slow, inexorable growth of these renal cysts, par...

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Polycystic kidney disease.

A number of inherited disorders result in renal cyst development. The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and caused by mutation in PKD1 or PKD2. The PKD1 protein, polycystin-1, is a large receptor-like protein, whereas polycystin-2 is a transient receptor potential channel. The polycystin complex localizes to prim...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2008

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2007060665